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Fakultät BCI

Research Paper: Intermediates and shunt products of massiliachelin biosynthesis in Massilia sp. NR 4-1

Intermediates shunt products of massiliachelin biosynthesis in Massilia sp. Nr 4-1 Bitte Bildnachweis einfügen

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Abstract: 

Siderophores are small molecules secreted by microorganisms in order to scavenge iron from the environment. An example is the thiazoline-containing natural product massiliachelin, which is produced by Massilia sp. NR 4-1 under iron-deficient conditions. Based on experimental evidence and genome analysis, it was suspected that this bacterium synthesizes further iron-chelating molecules. After a thorough inspection of its metabolic profile, six previously overlooked compounds were isolated that were active in the chrome azurol S (CAS) assay. Mass spectrometric measurements and nuclear magnetic resonance spectroscopic analyses identified these compounds as possible biosynthetic intermediates or shunt products of massiliachelin. Their bioactivity was tested against one Gram-positive and three Gram-negative bacteria.

 

Das Paper "Intermediates and shunt products of massiliachelin biosynthesis in Massilia sp. NR 4-1" ist zu finden unter https://www.beilstein-journals.org/bjoc/articles/19/69. Viel Spaß beim Lesen.