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Fakultät BCI
Gruppe Technische Biokatalyse

Dr.-Ing. Lea Winand

Forschungsfelder

• Biokatalytische Produktion von Naturstoffen

• Enzymatische und mikrobielle Biotransformationen

• Enzymreaktoren

 

 

Zelle mit Puzzleteilen und chemischen Strukturformeln
Cover Feature: Myxococcus xanthus as Host for the Production of Benzoxazoles (ChemBioChem 5/2023)

Auszeichnungen

• 2023: Dissertationspreis der Fakultät Bio- und Chemieingenieurwesen der TU Dortmund

• 2023: Ulfert-Onken-Preis der Biotechnologie

Publikationen

L. Winand, S. Theisen, S. Lütz, K. Rosentha, M. Nett
Immobilization of the Amidohydrolase MxcM and Its Application for Biocatalytic Flow Synthesis of Pseudochelin A
Catalysts. 2023, 13(2), 229. doi:10.3390/catal13020229

L. Winand, L. Lernoud, S. A. Meyners, K. Kuhr, W. Hiller, M. Nett 
Myxococcus xanthus as Host for the Production of Benzoxazoles
ChemBioChem. 2023, 24(5), e202200635. doi:10.1002/cbic.202200635

D. J. Vollmann, L. Winand, M. Nett
Emerging concepts in the semisynthetic and mutasynthetic production of natural products
Curr. Opin. Biotech. 2022, 77, 102761. doi:10.1016/j.copbio.2022.102761

B. K. Lombe, L. Winand, J. Diettrich, M. Töbermann, W. Hiller, M. Kaiser, M. Nett
Discovery, Biosynthetic Origin, and Heterologous Production of Massinidine, an Antiplasmodial Alkaloid
Org. Lett. 2022, 24(15), 2935–2939. doi:10.1021/acs.orglett.2c00963

L. Winand, P. Schneider, S. Kruth, N.-J. Greven, W. Hiller, M. Kaiser, J. Pietruszka, M. Nett
Mutasynthesis of Physostigmines in Myxococcus xanthus
Org. Lett. 2021, 23(16), 6563–6567. doi:10.1021/acs.orglett.1c02374

L. Winand, D. J. Vollmann, J. Hentschel, M. Nett
Characterization of a Solvent-Tolerant Amidohydrolase Involved in Natural Product Heterocycle Formation
Catalysts. 2021, 11(8), 892. doi:10.3390/catal11080892

L. Winand, A. Sester, M. Nett
Bioengineering of Anti-Inflammatory Natural Products
ChemMedChem. 2021, 16(5), 767–776. doi:10.1002/cmdc.202000771

A. Sester, L. Winand, S. Pace, W. Hiller, O. Werz, M. Nett
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered Myxococcus xanthus Strain
J. Nat. Prod. 2019, 82(9), 2544–2549. doi:10.1021/acs.jnatprod.9b00403

J. Korp, L. Winand, A. Sester, M. Nett
Engineering Pseudochelin Production in Myxococcus xanthus
Appl. Environ. Microbiol. 2018, 84(22). doi:10.1128/AEM.01789-18