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Fakultät BCI

Research Paper: Mutasynthesis of Physostigmines in Myxococcus xanthus

TOC © TBL​/​TU Dortmund

Abstract

The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.

Das Paper ist zu finden unter https://pubs.acs.org/doi/10.1021/acs.orglett.1c02374. Viel Spaß beim Lesen.