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Fakultät BCI

Microbial Cell Factories (Nett / Winand)

Mankind has used microbes and their metabolic performance for centuries, e.g. for baking bread or brewing beer. In contrast, the recombinant production of pharmaceuticals or the fine-tuning of metabolic networks in rationally designed microbial cells are comparatively new concepts. In our research, we engineer the bacteria Escherichia coli and Myxococcus xanthus in order to produce chemicals of interests from renewable carbon sources. For this purpose, we also develop tools facilitating the refactoring of biosynthetic pathways in these organisms.

[1] Korp, J.; Winand, L.; Sester, A.; Nett, M. Engineering pseudochelin production in Myxococcus xanthus. Applied and Environmental Microbiology 84, e01789-18 (2018) https://doi.org/10.1128/AEM.01789-18

[2] Kruth, S.; Schibajew, L.; Nett, M. Biocatalytic production of the antibiotic aurachin D in Escherichia coli. AMB Express, 12, 138 (2022) https://doi.org/10.1186/s13568-022-01478-8

[3] Winand, L.; Lernoud, L.; Meyners, S.A.; Kuhr, K.; Hiller, W.; Nett, M. Myxococcus xanthus as host for the production of benzoxazoles. ChemBioChem 24, e202200635 (2023) https://doi.org/10.1002/cbic.202200635

Journal ChemBioChem -  Myxococcus xanthus as Host for the Production of Benzoxazoles © ChemBioChem​/​Wiley
Myxococcus xanthus as Host for the Production of Benzoxazoles
Aurachin C synthesis © TBL​/​TU Dortmund