Genome Mining for Bioactive Small Molecules and Enzymes (Nett)
In recent years, genomic analyses have illuminated the proficiency of microorganisms and plants for the production of bioactive molecules - underappreciated for years based on conventional isolation programs - and have set the foundation for a new paradigm in natural product discovery based on genome mining. We exploit this strategy for the identification of novel producer organisms and enzymes that may have applied value as biocatalysts.
[1] Lombe, B. K.; Winand, L.; Dietrich, J.; Töbermann, M.; Hiller, W.; Kaiser, M.; Nett, M. Discovery, biosynthetic origin, and heterologous production of massinidine, an antiplasmodial alkaloid. Organic Letters 24, 2935-2939 (2022) https://doi.org/10.1021/acs.orglett.2c00963
[2] Steinmetz, T.; Lindig, A.; Lütz, S.; Nett, M. Molecular networking-guided discovery of kyonggic acids in Massilia spp. European Journal of Organic Chemistry 27, e202400017 (2024) https://doi.org/10.1002/ejoc.202400017