Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

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Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

ServicePortal UniMail

Review: Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes

06/17/2023

Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processses

A new review article has been published.

Abstract:

Aurachins are farnesylated quinolone alkaloids of bacterial origin and excellent inhibitors of the respiratory chain in pro- and eukaryotes. Therefore, they have become important tool compounds for the investigation of electron transport processes and they also serve as lead structures for the development of antibacterial and antiprotozoal drugs. Especially aurachin D proved to be a valuable starting point for structure-activity relationship studies. Aurachin D is a selective inhibitor of the cytochrome bd oxidase, which has received increasing attention as a target for the treatment of infectious diseases caused by mycobacteria. Furthermore, aurachin D possesses remarkable activities against Leishmania donovani, the causative agent of leishmaniasis. Aurachins are naturally produced by myxobacteria of the genus Stigmatella as well as by some Streptomyces and Rhodococcus strains. The recombinant production of these antibiotics turned out to be challenging due to their complex biosynthesis and their inherent toxicity. Recently, the biotechnological production of aurachin D was established in E. coli with a titer which is higher than previously reported from natural producer organisms.

The review "Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes" can be found at https://www.mdpi.com/2079-6382/12/6/1067. Enjoy reading.