Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

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Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

ServicePortal UniMail

Research Paper: Myxococcus xanthus as Host for the Production of Benzoxazoles

12/09/2022

Myxococcus xanthus as Host for the Production of Benzoxazoles

A new scientific article has been published.

Abstract:

Benzoxazoles are important structural motifs in pharmaceutical drugs. Here, we present the heterologous production of 3-hydroxyanthranilate-derived benzoxazoles in the host bacterium Myxococcus xanthus following the expression of two genes from the nataxazole biosynthetic gene cluster of Streptomyces sp. Tü 6176. The M. xanthus expression strain achieved a benzoxazole titer of 114.6±7.4 mg L-1 upon precursor supplementation, which is superior to other bacterial production systems. Crosstalk between the heterologously expressed benzoxazole pathway and the endogenous myxochelin pathway led to the combinatorial biosynthesis of benzoxazoles featuring a 2,3-dihydroxybenzoic acid (2,3-DHBA) building block. Subsequent in vitro studies confirmed that this crosstalk is not only due to the availability of 2,3-DHBA in M. xanthus, rather, it is promoted by the adenylating enzyme MxcE from the myxochelin pathway, which contributes to the activation of aryl carboxylic acids and delivers them to benzoxazole biosynthesis.

The paper"Myxococcus xanthus as Host for the Production of Benzoxazoles" can be found at https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202200635. Enjoy reading.