Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

ServicePortal UniMail

Contrast Deutsch

Location & approach

By car

The campus of Dortmund University of Technology is located near the Dortmund West motorway junction, where the A45 Sauerland route crosses the B1/A40 Ruhr expressway. The Dortmund-Eichlinghofen exit on the A45 motorway leads to the South Campus, the Dortmund-Dorstfeld exit on the A40 motorway leads to the North Campus. The university is signposted at both exits.

By bus and train

The ‘Dortmund Universität’ S-Bahn station is located directly on the North Campus. From there, the S-Bahn line S1 runs every 20 or 30 minutes to Dortmund Central Station and in the opposite direction to Düsseldorf Central Station via Bochum, Essen and Duisburg. The university can also be reached by bus lines 445, 447 and 462. Timetable information can be found on the homepage of the Rhine-Ruhr transport association, and DSW21 also offers an interactive network map.

The H-Bahn

The H-Bahn is one of the landmarks of TU Dortmund University. Line 1 runs every 10 minutes between Dortmund Eichlinghofen and the Technology Centre via Campus South and Dortmund University S, while Line 2 runs every 5 minutes between Campus North and Campus South. It covers this route in two minutes.

By plane

From Dortmund Airport, you can take the AirportExpress to Dortmund Central Station in just over 20 minutes and from there take the S-Bahn to the university. Düsseldorf Airport, around 60 kilometers away, offers a wider range of international flight connections and can be reached directly by S-Bahn from the university station.

Plan of site & interactive map

The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent "Technologiepark".

> Go to interactive map

ServicePortal UniMail

Review: Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides

11/30/2021

A new review article has been published.

Abstract

As a robust, fast growing and genetically tractable organism, the budding yeast Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its applications range from the manufacturing of vaccines and hormones to bulk chemicals and biofuels. In recent years, major efforts have been undertaken to expand this portfolio to include structurally complex natural products, such as polyketides and nonribosomally synthesized peptides. These compounds often have useful pharmacological properties, which make them valuable drugs for the treatment of infectious diseases, cancer, or autoimmune disorders. In nature, polyketides and nonribosomal peptides are generated by consecutive condensation reactions of short chain acyl-CoAs or amino acids, respectively, with the substrates and reaction intermediates being bound to large, multidomain enzymes. For the reconstitution of these multistep catalytic processes, the enzymatic assembly lines need to be functionally expressed and the required substrates must be supplied in reasonable quantities. Furthermore, the production hosts need to be protected from the toxicity of the biosynthetic products. In this review, we will summarize and evaluate the status quo regarding the heterologous production of polyketides and nonribosomal peptides in S . cerevisiae. Based on a comprehensive literature analysis, prerequisites for a successful pathway reconstitution could be deduced, as well as recurring bottlenecks in this microbial host.

The paper can be found at https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01650-y. We hope you enjoy reading it.