Research Paper: Mutasynthesis of Physostigmines in Myxococcus xanthus
A new scientific article has been published.
Abstract
The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.
The paper can be found at https://pubs.acs.org/doi/10.1021/acs.orglett.1c02374. Enjoy reading.